Studienregister

Studienregister der Deutschen Gesellschaft für Urologie e.V.

SWITCH (09072008-13772)

AcronymISRCTNEudraCTClinicaltrials.govDRKS
09072008-137722008-005011-18NCT00732914

A Phase III Randomized Sequential Open-Label Study to Evaluate the Efficacy and Safety of Sorafenib Followed by Sunitinib Versus Sunitinib Followed by Sorafenib in the Treatment of First-Line Advanced / Metastatic Renal Cell Carcinoma

Status: Active

Purpose / Objectives

Primary Outcome

To evaluate if progression-free survival from randomization to progression or death during second-line therapy (total PFS) of sorafenib followed by sunitinib is at least as effective as sunitinib followed by sorafenib

Secondary Outcomes

    1. Time from randomization to progression during second-line therapy (total TTP)

    2. Time to first-line treatment failure (progression, death, discontinuation due to toxicity) descriptively in each arm

    3. PFS in first-line and second-line treatment, descriptively

    4. Overall survival, descriptively (data cut-off same as for primary endpoint)

    5. Disease Control Rate (DCR); Response rates in first-line and in second-line (CR, PR, SD according to RECIST criteria)

    6. Cardiotoxicity analysis by means of echocardiography and NT-pro BNP with an interim analysis after 100 patients of each arm have completed the study

    7. Safety and tolerability

     

      Diagnosis

      Patient attributes

      Age

      18-99

      Inclusion criteria

      1. Patients with metastatic / advanced RCC (all histologies), who are not suitable for cytokine therapy and for whom study medication constitutes first-line therapy

      2. Age > 18 years

      3. ECOG Performance Status of 0 or 1

      4. MSKCC prognostic score, low or intermediate

      5. Life expectancy of at least 12 weeks.

      6. Subjects with at least one uni-dimensional (for RECIST) measurable lesion. Lesions must be measured by CT/MRI-scan.

      7.

       

      Adequate bone marrow, liver and renal function as assessed by the following laboratory requirements to be conducted within 7 days prior to start of therapy:

      * Hemoglobin > 9.0 g/dl

      * Absolute neutrophil count (ANC) >1,500/mm3

      * Platelet count ³ 100,000/μl

      * Total bilirubin < 1.5 times the upper limit of normal

      * ALT and AST < 2.5 x upper limit of normal (< 5 x upper limit of normal for patients with liver involvement of their cancer)

      * Alkaline phosphatase < 4 x upper limit of normal

      * PT-INR/PT < 1.5 x upper limit of normal [Patients who are being therapeutically anticoagulated with an agent such as coumadin or heparin will be allowed to participate provided that no prior evidence of underlying abnormality in these parameters exists.]

      * Serum creatinine < 1.5 x upper limit of normal.

      8. Written Informed Consent

       

      Exclusion criteria

      1. History of cardiac disease: congestive heart failure >NYHA class 2; active CAD (MI more than 6 months prior to study entry is allowed); cardiac arrhythmias requiring antiarrhythmic therapy (beta blockers or digoxin are permitted) or uncontrolled hypertension.
      2. History of HIV infection or chronic hepatitis B or C
      3. Active clinically serious infections (> grade 2 NCI-CTC version 3.0)
      4. Symptomatic metastatic brain or meningeal tumors (unless the patient is > 6 months from definitive therapy, has a negative imaging study within 4 weeks of study entry and is clinically stable with respect to the tumor at the time of study entry)
      5. Patients with seizure disorder requiring medication (such as steroids or anti-epileptics)
      6. History of organ allograft
      7. Patients with evidence or history of bleeding diathesis
      8. Patients undergoing renal dialysis
      9. Previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study EXCEPT cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors [Ta, Tis & T1] or any cancer curatively treated > 3 years prior to study entry.
      10. Pregnant or breast-feeding patients. Women of childbearing potential must have a negative pregnancy test performed within 7 days of the start of treatment. Both men and women enrolled in this trial must use adequate barrier birth control measures during the course of the trial and 3 months after the completion of trial.
      11. Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results
      12. Any condition that is unstable or could jeopardize the safety of the patient and their compliance in the study
      13. Patients unable to swallow oral medications
      14. Known allergy to sunitinib or sorafenib or one of its constituents

      Excluded therapies and medications, previous and concomitant:

      1. Anticancer chemotherapy or immunotherapy during the study or within 4 weeks of study entry.
      2. Radiotherapy during study or within 3 weeks of start of study drug. (Palliative radiotherapy will be allowed). Major surgery within 4 weeks of start of study
      3. Autologous bone marrow transplant or stem cell rescue within 4 months of study
      4. Use of biologic response modifiers, such as G-CSF, within 3 week of study entry.

        [G-CSF and other hematopoietic growth factors may be used in the management of acute toxicity such as febrile neutropenia when clinically indicated or at the discretion of the investigator; however they may not be substituted for a required dose reduction.] [Patients taking chronic erythropoietin are permitted provided no dose adjustment is undertaken within 2 months prior to the study or during the study]

      5. Investigational drug therapy outside of this trial during or within 4 weeks of study entry
      6. Prior exposure to the study drug.
      7. Any St. John's wort containing remedy

      Trial design

      • Phase III

      Intervention

      Arms Assigned Interventions

       

      1: Active Comparator

      • Sunitinib (first-line) followed by Sorafenib (second-line)
      • Drug: Sunitinib (Sutent)
      • Sunitinib 50 mg once daily 4 weeks on, 2 weeks off, and after discontinuation (due to PD or toxicity), followed by sorafenib 400 mg BID

       

      2: Experimental

      • Sorafenib (first-line) followed by Sunitinib (second-line)
      • Drug: Sorafenib (Nexavar)
      • Sorafenib 400 mg BID, followed by Sunitinib 50 mg once daily 4 weeks on, 2 weeks off, and after discontinuation (due to PD or toxicity)

       

      Documents (password protected)

      Responsibilities in overall trial

      Sponsor representative

      Prof. Dr. med. Maurice Stephan Michel

      National Coordinating Investigator

      Prof. Dr. med. Maurice Stephan Michel

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